What Is MOTS-c?
MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA region, with the sequence MRWQEMGYIFYPRKLR. It has been studied in preclinical metabolic signalling research and is supplied as a laboratory reference material.
Published 2026-08-22 · Updated 2026-08-22 · Reviewed by the Lana editorial team
Molecular information
Sequence MRWQEMGYIFYPRKLR; molecular formula C101H152N28O22S2; molecular weight approximately 2174.6 g/mol; CAS 1627580-64-6.
What mechanisms have been investigated?
Published preclinical research has examined MOTS-c in relation to AMPK signalling and cellular metabolic stress responses.
Regulatory and research status
Not an approved therapeutic product. Supplied for in-vitro laboratory research only.